2024年

Tauchi T, Moriya S, Okabe S, Kazama H, Miyazawa K, Takano N.
Vitamin K2 sensitizes the efficacy of venetoclax in acute myeloid leukemia by targeting the NOXA-MCL-1 pathway.
PLoS One. 2024 Jul 25;19(7):e0307662. （研究概要）

2023年

Takano N, Hiramoto M, Yamada Y, Kokuba H, Tokuhisa M, Hino H, Miyazawa K.
Azithromycin, a potent autophagy inhibitor for cancer therapy, perturbs cytoskeletal protein dynamics.
Br J Cancer. 2023 May;128(10):1838-1849. （プレスリリース）

Moriya S, Kazama H, Hino H, Takano N, Hiramoto M, Aizawa S, Miyazawa K.
Clarithromycin overcomes stromal cell-mediated drug resistance against proteasome inhibitors in myeloma cells via autophagy flux blockage leading to high NOXA expression.
PLoS One. 2023 Dec 1;18(12):e0295273.

2022年

Yamashita G, Takano N, Kazama H, Tsukahara K, Miyazawa K
p53 regulates lysosomal membrane permeabilization as well as cytoprotective autophagy in response to DNA-damaging drugs.
Cell Death Discov. 2022; 8: 502. （プレスリリース）

Miyake K, Takano N, Kazama H, Kikuchi H, Hiramoto M, Tsukahara K, Miyazawa K
Ricolinostat enhances adavosertib-induced mitotic catastrophe in TP53-mutated head and neck squamous cell carcinoma cells.
Int J Oncol. 2022 May; 60(5): 54. （プレスリリース）

Suzuki S, Ogawa M, Miyazaki M, Ota K, Kazama H, Hirota A, Takano N, Hiramoto M, Miyazawa K.
Lysosome targeted drug combination induces multiple organelle dysfunctions and non canonical death in pancreatic cancer cells.
Oncol Rep. 2022 Feb;47(2):40. （プレスリリース）

2021年

Miyazaki M, Hiramoto M, Takano N, Kokuba H, Takemura J, Tokuhisa M, Hino H, Kazama H, Miyazawa K.
Targeted disruption of GAK stagnates autophagic flux by disturbing lysosomal dynamics.
Int J Mol Med. 2021 Oct;48(4):195

Hattori K, Takano N, Kazama H, Moriya S, Miyake K, Hiramoto M, Tsukahara K, Miyazawa K.
Induction of synergistic non-apoptotic cell death by simultaneously targeting proteasomes with bortezomib and histone deacetylase 6 with ricolinostat in head and neck tumor cells.
Oncol Lett. 2021 Sep;22(3):680

Toriyama K, Takano N, Kokuba H, Kazama H, Moriya S, Hiramoto M, Abe S, Miyazawa K.
Azithromycin enhances the cytotoxicity of DNA-damaging drugs via lysosomal membrane permeabilization in lung cancer cells.
Cancer Sci. 2021 Aug;112(8):3324-3337.

Miyahara K, Takano N, Yamada Y, Kazama H, Tokuhisa M, Hino H, Fujita K, Barroga E, Hiramoto M, Handa H, Kuroda M, Ishikawa T, Miyazawa K.
BRCA1 degradation in response to mitochondrial damage in breast cancer cells.
Sci Rep. 2021 Apr 22;11(1):8735.

2020年

Hino H, Iriyama N, Kokuba H, Kazama H, Moriya S, Takano N, Hiramoto M, Aizawa S,?Miyazawa K.
Abemaciclib induces atypical cell death in cancer cells characterized by formation of cytoplasmic vacuoles derived from lysosomes
Cancer Sci. 2020 Jun;111(6):2132-2145.

Tanaka H, Hino H, Moriya S, Kazama H, Miyazaki M, Takano N, Hiramoto M, Tsukahara K,?Miyazawa K.
Comparison of autophagy inducibility in various tyrosine kinase inhibitors and their enhanced cytotoxicity via inhibition of autophagy in cancer cells in combined treatment with azithromycin
Biochem Biophys Rep. 2020 Mar 17;22:100750

Miyazawa S, Moriya S, Kokuba H, Hino H,?Takano N,?Miyazawa K.
Vitamin K?2?induces non-apoptotic cell death along with autophagosome formation in breast cancer cell lines
Breast Cancer. 2020 Mar;27(2):225-235

Teraoka S, Muguruma M,?Takano N, Miyahara K, Kawate T, Kaise H, Yamada K,?Miyazawa K, Ishikawa T.
Association of BRCA Mutations and BRCAness Status With Anticancer Drug Sensitivities in Triple-Negative Breast Cancer Cell Lines
J Surg Res. 2020 Jun;250:200-208.

Yokota A, Hiramoto M, Hino H, Tokuhisa M, Miyazaki M, Kazama H,?Takano N,?Miyazawa K.
Sequestosome 1 (p62) accumulation in breast cancer cells suppresses progesterone receptor expression via argonaute 2
Biochem Biophys Res Commun. 2020 Aug 12:S0006-291X(20)31446-7.

2019年

Tsugawa Y，Hiramoto M, Imai T
Estrogen induces estrogen receptor α expressionand hepatocyte proliferation in late pregnancy.
Biochemical and Biophysical Research Communications 511(3):592-596, 2019

Ota K，Okuma T, Lorenzo A, Yokota A, Hino H, Kazama H, Moriya S, Takano N, Hiramoto M,?Miyazawa K.
Fingolimod sensitizes EGFR wild?type non?small cell lung cancer cells to lapatinib or sorafenib and induces cell cycle arrest.
Oncol Reports 42(1):231-242, 2019

Miyazawa S，Moriya S, Kokuba H, Hino H, Takaano N, Miyazawa K
Vitamin K2 induces non-apoptotic cell death along with autophagosome formation in breast cancer cell lines.
Breast Cancer , Epub 2019 Oct 17

2018年

Kazama H, Hiramoto M, Miyahara K, Takano N, Miyazawa K　
Designing an effective drug combination for ER stress loading in cancer therapy using a real-time monitoring system.　
Biochem Biophys Res Commun. 2018 Jun 18;501(1):286-292

Saito Y, Moriya S, Kazama H, Hirasawa K, Miyahara K, Kokuba H, Hino H, Kikuchi H, Takano N, Hiramoto M, Tsukahara K, Miyazawa K.
Amino acid starvation culture condition sensitizes EGFR-expressing cancer cell lines to gefitinib-mediated cytotoxicity by inducing atypical necroptosis.
Int J Oncol. 52(4):1165-1177, 2018